From the record
“The Louisville and Nashville Depot, located at 101 East Railroad Street in Nashville, Illinois, is the city's former Louisville and Nashville Railroad station. The station was built in 1885 as part of the L&N's expansion through Southern Illinois in the 1880s.”
Wikipedia article Nashville station (Illinois), CC BY-SA 4.0.
One of 3 National Register listings published here for Washington County · listed in 1985 · category: Building.
Sources: the Wikipedia article · the case file at the National Archives · the National Register database, National Park Service