| February 2000 | Tornado (F3) | Cairo | 6 killed, 15 hurt, $3,500,000 | A strong tornado tore through northern Grady County, then crossed into extreme northwest Thomas County. Fifteen homes were destroyed and numerous damaged. Fifteen persons were injured, mostly from flying debris. Six fatalities were confirmed by the Georgia Emergency Management Agency: four deaths in mobile homes and two in a woodframe home. Scores of pecan trees were uprooted, pine trees snapped and power lines toppled. Farmers suffered major losses to irrigation equipment, trailers and shelters. Eight chicken houses were flattened, killing a half million chickens. Grady County was declared a federal disaster area. Reported by the Grady County EMA. |
| March 2019 | Tornado (EF2) | Cairo | 2 hurt, $1,000,000 | An EF-2 tornado, with maximum winds of 120 mph, tracked 2.7 miles across Grady County in the Cairo area. The tornado touched down on Monrovia Nursery, downing 100s of potted plants and numerous trees in the forest. The tornado continued to track|northeastward, downing numerous trees, many of which fell on homes causing structural damage. In one of the harder hit areas, the roof was torn off of a single family home and a carport was destroyed. The tornado eventually lifted northeast of Hwy 84. Two injuries were sustained from the storm. Damage cost was estimated. |
| November 1995 | Tornado (F1) | Cairo | $200,000 | A tornado caused intermittent damage on a track parallel to GA Highway 188. One unoccupied moble home was completely destroyed. Several other frame homes received serious damage. |
| January 2006 | Thunderstorm Wind | Cairo | $150,000 | Straight-line winds whipped through the Cairo Country Club area, uprooting and snapping off pine trees, and downing power lines. In the new neighborhood of Hawthorne Trails, the winds destroyed 60 percent of the wood trusses of a frame house. The storm then moved across Lake Jenna and dissipated before reaching Sutton Mill Road NW. About 35 homes in the country club area were without power for nearly four hours. Damage to homes was minimal. Reported by the Grady County EMA. |
| September 2023 | Thunderstorm Wind | Cairo | $100,000 | Numerous trees and power lines were blown down in Cairo with trees down on several houses. |
| February 2003 | Tornado (F1) | Cairo | $75,000 | A tornado briefly touched down on Ridge Road, just south of the Grady-Mitchell county line. It damaged two homes, and knocked down trees and power lines. The tornado moved northeast into southern Mitchell County. Reported by the Grady County EMA. |
| February 2007 | Thunderstorm Wind | Cairo | $25,000 | The Grady County EMA reported major damage to a mobile home. Several trees were down. |
| March 2006 | Thunderstorm Wind | Cairo | $25,000 | A microburst blew down numerous trees and some power lines from near the intersection of Robert Willis and Harper Roads east to Brumbley Creek (north of State Road 188). One home on Harper Road lost part of its roof. Damage survey conducted by the NWS Tallahassee WCM. |
| April 2011 | Thunderstorm Wind | Cairo | $20,000 | Trees and power lines were blown down across the county. The monetary damage figure provided is a rough estimate. |
| March 2018 | Thunderstorm Wind | Cairo | $10,000 | A large pine tree was blown down onto a vehicle along Highway 84 near Vereen Bell Road. No injuries occurred. |
| February 2007 | Thunderstorm Wind | Cairo | $10,000 | The Grady County EMA reported a roof blown off a house. Several trees were down. |
| June 2018 | Thunderstorm Wind | Cairo | $5,000 | Broken power poles were reported in Grady county. |
| July 2012 | Thunderstorm Wind | Cairo | $4,000 | Several large trees were blown down in Cairo, and one building had structural damage. Monetary damage was estimated. |
| March 2026 | Thunderstorm Wind | Cairo | $2,000 | There was a broken pole on Wight Road. |
| June 2025 | Thunderstorm Wind | Cairo | $2,000 | Power lines were down in Cairo. |
| June 2014 | Thunderstorm Wind | Cairo | $2,000 | Numerous trees were blown down across the county. |
| December 2012 | Thunderstorm Wind | Cairo | $2,000 | Trees were blown down on Highway 93 North. Monetary damage was estimated. |
| May 2012 | Thunderstorm Wind | Cairo | $2,000 | Trees were blown down around Cairo. Monetary damage was estimated. |
| June 2004 | Thunderstorm Wind | Cairo | $2,000 | Downed trees on power lines reported by the Grady County EMA. |
| February 2017 | Thunderstorm Wind | Cairo | $1,000 | A power pole was broken in the Hawthorne area. |
| February 2017 | Thunderstorm Wind | Cairo | $1,000 | Trees and power lines were blown down along Pine Circle SW and 1st Street in Cairo. |
| February 2017 | Thunderstorm Wind | Cairo | $1,000 | A power line was blown down near Hall Road. |
| July 2012 | Thunderstorm Wind | Cairo | $1,000 | A large tree was blown down on 4th Ave SE in Cairo near Southside Elementary School. Power was out in the area. Monetary damage was estimated. |
| July 2012 | Thunderstorm Wind | Cairo | $1,000 | A tree was blown down on Highway 84W. Monetary damage was estimated. |
| July 2012 | Thunderstorm Wind | Cairo | $1,000 | A tree was blown down along Highway 111N. Monetary damage was estimated. |
| June 2007 | Thunderstorm Wind | Cairo | $1,000 | Several trees were down on roads north of Cairo. |
| August 2007 | Thunderstorm Wind | Cairo | $1,000 | Numerous trees were down in eastern portions of the county. |
| May 2006 | Thunderstorm Wind | Cairo | $1,000 | The Georgia DOT reported several trees down along Ridge Road. |
| June 2002 | Thunderstorm Wind | Cairo | $500 | A few downed trees reported by Decatur/Grady 911. |
| September 1997 | Thunderstorm Wind | Cairo | $500 | no account filed |
| September 1997 | Thunderstorm Wind | Cairo | $500 | no account filed |
| June 2008 | Thunderstorm Wind | Cairo | $250 | Three large trees and numerous big limbs were scattered across the golf course at the Cairo Country Club. |
| August 2000 | Thunderstorm Wind | Cairo | $200 | A few trees down. Reported by Grady County 911. |
| August 1995 | Thunderstorm Wind | Cairo | $100 | Sheriff's office reported several trees blown down. |
| August 2024 | Thunderstorm Wind | Cairo | - | There were several large tree limbs down and blowing around in the Cairo area. |
| July 2023 | Thunderstorm Wind | Cairo | - | A tree was blown down onto Highway 84 just outside of Cairo. |
| July 2023 | Thunderstorm Wind | Cairo | - | Three trees were blown down in the Cairo area. |
| June 2023 | Thunderstorm Wind | Cairo | - | Several trees were blown down across Grady county. |
| August 2022 | Thunderstorm Wind | Cairo | - | Several trees and power lines were blown down. |
| May 2021 | Thunderstorm Wind | Cairo | - | A couple of trees were blown down. |
| August 2021 | Thunderstorm Wind | Cairo | - | A tree was blown down in Cairo. |
| April 2020 | Thunderstorm Wind | Cairo | - | A few trees were blown down. |
| April 2020 | Thunderstorm Wind | Cairo | - | Several trees were blown down. |
| March 2019 | Thunderstorm Wind | Cairo | - | A wind gust of 102 mph was measured by a Georgia mesonet site near the tornado track just south of Cairo. |
| May 2019 | Thunderstorm Wind | Cairo | - | Multiple trees were blown down. |
| July 2015 | Thunderstorm Wind | Cairo | - | A tree was blown down across the road near the intersection of Upper Hawthorne Trail and Highway 84. |
| June 2015 | Thunderstorm Wind | Cairo | - | Several trees were blown down around Grady County. |
| July 2015 | Thunderstorm Wind | Cairo | - | Two trees were blown down along Highway 93. |
| July 2015 | Thunderstorm Wind | Cairo | - | Several trees were blown down in Cairo. |
| June 2012 | Heavy Rain | Cairo | - | WCTV relayed a viewer report of 3.50 inches of rain on the north side of Cairo in a roughly 3 hour period. |
| May 2010 | Thunderstorm Wind | Cairo | - | A metal framed greenhouse partially collapsed and an oak tree was uprooted. |
| February 2009 | Thunderstorm Wind | Cairo | - | Several trees were down. |
| June 2008 | Thunderstorm Wind | Cairo | - | There were several trees down in Cairo. |
| April 2006 | Hail | Cairo | - | Penny to nickel size hail reported just east of Cairo by the Grady County EMA. |
| March 2005 | Hail | Cairo | - | Marble to quarter size hail reported by NWS Peachtree City. |
| April 2003 | Thunderstorm Wind | Cairo | - | Several trees down across the intersection of State Roads 93 and 111. Reported by Grady County 911. |
| April 2003 | Hail | Cairo | - | Dime size hail reported by Grady County 911. |
| January 1995 | Hail | Cairo | - | Two inch hail fell at Burnetts Creek. |
| March 2026 | Thunderstorm Wind | Cairo | - | no account filed |
| May 2024 | Hail | Cairo | - | no account filed |